What is the drawback that occurs in using ion exchange chromatography

what-is-the-drawback-that-occurs-in-using-ion-exchange-chromatography

What is the drawback that occurs in using ion exchange chromatography on sulphonated polystyrene resin and colourimetry for amino-acid analysis?

A. Less accuracy

B. Low resolution

C. Inconvenient to handle many individual samples

D. Slow in operation

This question was addressed to me in an internship interview.

This intriguing question originated from Amino-Acid Analysers topic in chapter Chromatography of Analytical Instrumentation

Right option is C. Inconvenient to handle many individual samples

The explanation: When ion exchange chromatography is used for amino-acid analysis, high accuracy is obtained. It is inconvenient to handle many individual samples and cleaning of glassware is laborious.