CRM1 is necessary for the export of mRNA.
A. True
B. False
This question was posed to me by my college director while I was bunking the class.
This key question is from Nuclear Export in chapter Nuclear Export & Post Mendelian Genetics of Cytogenetics
The correct option is B. False
To explain: LMB or leptomycin B treatment prevents the export by CRM1 as it binds to the NES binding site. However, it doesn’t affect export of mRNA which shows that is via some other mechanism.