CRM1 is necessary for the export of mRNA. A. True B. False This

crm1-is-necessary-for-the-export-of-mrna-a-true-b-false-this

CRM1 is necessary for the export of mRNA.

A. True

B. False

This question was posed to me by my college director while I was bunking the class.

This key question is from Nuclear Export in chapter Nuclear Export & Post Mendelian Genetics of Cytogenetics

The correct option is B. False

To explain: LMB or leptomycin B treatment prevents the export by CRM1 as it binds to the NES binding site. However, it doesn’t affect export of mRNA which shows that is via some other mechanism.