Deletion of which domain of ARS would give the least replication

deletion-of-which-domain-of-ars-would-give-the-least-replication

Deletion of which domain of ARS would give the least replication rate in eukaryotes?

A. A domain

B. B1 domain

C. B2 domain

D. B3 domain

I got this question in unit test.

I’d like to ask this question from DNA Replication Eukaryotes topic in chapter DNA Replication of Cytogenetics

The correct choice is A. A domain

The best I can explain: The 11bp ‘A domain’ is the primary functional area of the ARS. Mutation in this domain gives 0% functionality of ORC so lease replication. Other mutations also reduce replication rate but not to such extent.