The deleterious effect of various coatings on drug dissolution is shown in orders below. Which one of them is the correct order?
A. Enteric coat > sugar coat > nonenteric film coat
B. Enteric coat > nonenteric film coat > sugar coat
C. Nonenteric film coat > sugar coat > enteric coat
D. Sugar coat > enteric coat > nonenteric film coat
The question was posed to me in a job interview.
This interesting question is from Dosage Form Factors Affecting Drug Absorption in chapter Absorption of Drugs of Drug Biotechnology
Right choice is A. Enteric coat > sugar coat > nonenteric film coat
The explanation is: The deleterious effect of various coatings on drug dissolution rate is in the following order enteric coat > sugar coat > nonenteric film coat. The dissolution rate of some coatings changes while they age e.g. shellac coated tablets.