Defect in which of these genes produce an increased propensity

defect-in-which-of-these-genes-produce-an-increased-propensity

Defect in which of these genes produce an increased propensity to breast cancer?

A. MTHF poly glu

B. PKC

C. BRCA 1

D. XPB

I had been asked this question in an interview for job.

I’d like to ask this question from Repair of DNA Damage: Recombinational and Bypass topic in division DNA Mutation, DNA Repair, Transposable Elements of Cytogenetics

Correct answer is C. BRCA 1

The best explanation: Defects in the genes of BRCA 1 and BRCA 2 increases the propensity of breast cancer to 80%.  On the other hand option a, b and d doesn’t directly play a role in breast cancer.